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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50357134
Substrate
n/a
Meas. Tech.
ChEMBL_787466 (CHEMBL1919385)
IC50
115±n/a nM
Citation
 Luker, T; Bonnert, R; Brough, S; Cook, AR; Dickinson, MR; Dougall, I; Logan, C; Mohammed, RT; Paine, S; Sanganee, HJ; Sargent, C; Schmidt, JA; Teague, S; Thom, S Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. Bioorg Med Chem Lett 21:6288-92 (2011) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50357134
Synonyms:
CHEMBL1917448
Type:
Small organic molecule
Emp. Form.:
C19H19NO5S
Mol. Mass.:
373.423
SMILES:
COc1cccc(c1)S(=O)(=O)c1c(C)n(CC(O)=O)c2ccc(C)cc12
Structure:
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