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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50341760
Substrate
n/a
Meas. Tech.
ChEMBL_789313 (CHEMBL1924480)
IC50
120±n/a nM
Citation
 Yun, W; Ahmad, M; Chen, Y; Gillespie, P; Conde-Knape, K; Kazmer, S; Li, S; Qian, Y; Taub, R; Wertheimer, SJ; Whittard, T; Bolin, D Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors. Bioorg Med Chem Lett 21:7205-9 (2011) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
DGAT1_RAT | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 | Diglyceride acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
56890.70
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
498
Sequence:
MGDRGGAGSSRRRRTGSRVSVQGGSGPKVEEDEVREAAVSPDLGAGGDAPAPAPAPAHTRDKDRQTSVGDGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLSLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLIIASNIFIVATFQIEKRLSVGALTEQMGLLLHVVNLATIICFPAAVALLVESITPVGSLFALASYSIIFLKLSSYRDVNLWCRQRRVKAKAVSAGKKVSGAAAQNTVSYPDNLTYRDLYYFIFAPTLCYELNFPRSPRIRKRFLLRRVLEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELLQFGDREFYRDWWNAESVTYFWQNWNIPVHKWCIRHFYKPMLRLGSNKWMARTGVFWASAFFHEYLVSIPLRMFRLWAFTAMMAQVPLAWIVNRFFQGNYGNAAVWVTLIIGQPVAVLMYVHDYYVLNYDAPVGA
  
Inhibitor
Name:
BDBM50341760
Synonyms:
2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid{6-[(2-Methoxyethyl)methylamino]pyridin-3-yl}amide | CHEMBL1766813
Type:
Small organic molecule
Emp. Form.:
C20H19F3N4O3
Mol. Mass.:
420.3851
SMILES:
COCCN(C)c1ccc(NC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cn1
Structure:
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