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Target
Histamine H3 receptor
Ligand
BDBM50360900
Substrate
n/a
Meas. Tech.
ChEMBL_795469 (CHEMBL1937474)
Ki
85±n/a nM
Citation
 Hudkins, RL; Aimone, LD; Dandu, RR; Dunn, D; Gruner, JA; Huang, Z; Josef, KA; Lyons, JA; Mathiasen, JR; Tao, M; Zulli, AL; Raddatz, R 4,5-dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonists. Bioorg Med Chem Lett 22:194-8 (2011) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50360900
Synonyms:
CHEMBL1935112
Type:
Small organic molecule
Emp. Form.:
C18H25N3O2
Mol. Mass.:
315.41
SMILES:
CC1CC(=O)NN=C1c1ccc(OCCCN2CCCC2)cc1 |c:6|
Structure:
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