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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50364550
Substrate
n/a
Meas. Tech.
ChEMBL_802832 (CHEMBL1953650)
EC50
1750±n/a nM
Citation
 Semple, G; Lehmann, J; Wong, A; Ren, A; Bruce, M; Shin, YJ; Sage, CR; Morgan, M; Chen, WC; Sebring, K; Chu, ZL; Leonard, JN; Al-Shamma, H; Grottick, AJ; Du, F; Liang, Y; Demarest, K; Jones, RM Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile. Bioorg Med Chem Lett 22:1750-5 (2012) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
GP119_RAT | Gpr119
Type:
PROTEIN
Mol. Mass.:
51687.59
Organism:
Rattus norvegicus
Description:
ChEMBL_1506411
Residue:
468
Sequence:
MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLADGSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTSSLVTGQTEQTPLKRANMSDPLRTCRG
  
Inhibitor
Name:
BDBM50364550
Synonyms:
CHEMBL1951019
Type:
Small organic molecule
Emp. Form.:
C20H23N5O4
Mol. Mass.:
397.4277
SMILES:
CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cncc(c2)C#N)c1C
Structure:
Search PDB for entries with ligand similarity: