Reaction Details Report a problem with these data
Target
Leukotriene A-4 hydrolase
Ligand
BDBM50046331
Substrate
n/a
Meas. Tech.
ChEMBL_96945 (CHEMBL706185)
Ki
15000±n/a nM
Citation
 Yuan, W; Zhong, Z; Wong, C; Haeggstrom, JZ; Wetterholm, A; Samuelsson, B Probing the inhibition of leukotriene A4 hydrolase based on its aminopeptidase activity Bioorg Med Chem Lett 1:551-556 (1991)    Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM50046331
Synonyms:
((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-acetic acid | (3-Amino-2-hydroxy-4-phenyl-butyrylamino)-acetic acid | CHEMBL306868
Type:
Small organic molecule
Emp. Form.:
C12H16N2O4
Mol. Mass.:
252.2664
SMILES:
N[C@@H](Cc1ccccc1)[C@H](O)C(=O)NCC(O)=O
Structure:
Search PDB for entries with ligand similarity: