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Found 671 with Last Name = 'yuan' and Initial = 'w'
TargetAdenosine receptor A2a(Homo sapiens (Human))TBA
LigandPNGBDBM493757(US10988455, Example 1(xcv))
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human adenosine A2A receptor assessed as inhibition constantMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50046316(2-Amino-3-(4-benzyloxy-phenyl)-propane-1-thiol | C...)
Affinity DataKi:  18nMAssay Description:Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50046314(3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid ...)
Affinity DataKi:  46nMAssay Description:Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50046316(2-Amino-3-(4-benzyloxy-phenyl)-propane-1-thiol | C...)
Affinity DataKi:  100nMAssay Description:Inhibition constant was determined against epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50449388(CHEMBL3127003)
Affinity DataKi:  140nMAssay Description:Mixed-type inhibition of electric eel AchE using acetylthiocholine as substrate after 15 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))TBA
LigandPNGBDBM50561034(CHEMBL4244287)
Affinity DataKi:  310nMAssay Description:Competitive inhibition of human ARG2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
China Medical University

Curated by ChEMBL
LigandPNGBDBM50234442(CHEMBL4069614)
Affinity DataKi:  570nMAssay Description:Mixed-type inhibition of bovine xanthine oxidase assessed as enzyme-inhibitor complex using xanthine as substrate after 60 secs by Lineweaver-Burk pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
China Medical University

Curated by ChEMBL
LigandPNGBDBM50234442(CHEMBL4069614)
Affinity DataKi:  940nMAssay Description:Mixed-type inhibition of bovine xanthine oxidase assessed as enzyme-inhibitor-substrate complex using xanthine as substrate after 60 secs by Lineweav...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50046314(3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid ...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition constant was determined against epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50046327(3-Amino-1,4-diphenyl-butan-2-one | CHEMBL70658)
Affinity DataKi:  1.40E+4nMAssay Description:Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50046331(((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-...)
Affinity DataKi:  1.50E+4nMAssay Description:Compound was tested for inhibitory activity against Leukotriene A4 hydrolase from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50046331(((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-...)
Affinity DataKi:  1.50E+4nMAssay Description:Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50279808((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyric acid me...)
Affinity DataKi:  5.00E+4nMAssay Description:Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50279808((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyric acid me...)
Affinity DataKi:  5.00E+4nMAssay Description:Compound was tested for inhibitory activity against Leukotriene A4 hydrolase from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTransforming growth factor beta-2 proprotein(Homo sapiens (Human))TBA
LigandPNGBDBM50615664(CHEMBL5288544)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of TGF-beta (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTransforming growth factor beta-2 proprotein(Homo sapiens (Human))TBA
LigandPNGBDBM172452(US9090625, 4 | US9260450, 4 | US9938289, 4)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of TGF-beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50542976(CHEMBL4636606 | US11535615, Example 1)
Affinity DataIC50: <10nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM50615665(CHEMBL5267324)
Affinity DataIC50:  11nMAssay Description:Inhibition of ALK5 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  12nMAssay Description:Inhibition of AChE in human erythrocytes using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109368(CHEMBL3601212)
Affinity DataIC50:  13nMAssay Description:Inhibition of Keap1 Kelch domain/FITC-9mer Nrf2 (unknown origin) interaction after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109368(CHEMBL3601212)
Affinity DataIC50:  14nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  15nMAssay Description:Inhibition of AChE in rat cortex using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50535176(CHEMBL4544116)
Affinity DataIC50:  16nMAssay Description:Inhibition of Keap1 Kelch domain/FITC-9mer Nrf2 (unknown origin) interaction after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109404(CHEMBL3601208)
Affinity DataIC50:  18nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)
Affinity DataIC50:  18nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  20nMAssay Description:Inhibition of autophosphorylation of recombinant his-tagged EGFR (amino acid 645-1186) (unknown origin) expressed in Sf-9 cells after 10 mins by time...More data for this Ligand-Target Pair
TargetPhosphatidylcholine-sterol acyltransferase(Homo sapiens (Human))
Dalhousie University

LigandPNGBDBM92615(Difluoroketone phospholipid analogue, 3)
Affinity DataIC50:  28nMpH: 7.5 T: 2°CAssay Description:The phospholipase A2 activity of LCAT was assayed using lecithin and apoA-I containing [9,10-3H] dipalmitoylphosphatidylcholine (DPPC) and measuremen...More data for this Ligand-Target Pair
In DepthDetails
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataIC50:  31nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109371(CHEMBL3601215)
Affinity DataIC50:  34nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109367(CHEMBL3601211)
Affinity DataIC50:  37nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109396(CHEMBL3601221)
Affinity DataIC50:  42nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109366(CHEMBL3601210)
Affinity DataIC50:  42nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109392(CHEMBL3601217)
Affinity DataIC50:  47nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50615669(CHEMBL5277365)
Affinity DataIC50:  50nMAssay Description:Inhibition of human NTPDase1More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109369(CHEMBL3601213)
Affinity DataIC50:  50nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109365(CHEMBL3601209)
Affinity DataIC50:  54nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransforming growth factor beta-2 proprotein(Homo sapiens (Human))TBA
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50:  56nMAssay Description:Inhibition of TGF-beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))TBA
LigandPNGBDBM50534854(CHEMBL4544537)
Affinity DataIC50:  60nMAssay Description:Agonist activity at human RORgammatMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPhosphatidylcholine-sterol acyltransferase(Homo sapiens (Human))
Dalhousie University

LigandPNGBDBM92616(Difluoroketone phospholipid analogue, 4)
Affinity DataIC50:  60nMpH: 7.5 T: 2°CAssay Description:The phospholipase A2 activity of LCAT was assayed using lecithin and apoA-I containing [9,10-3H] dipalmitoylphosphatidylcholine (DPPC) and measuremen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetPhosphatidylcholine-sterol acyltransferase(Homo sapiens (Human))
Dalhousie University

LigandPNGBDBM92614(Difluoroketone phospholipid analogue, 2)
Affinity DataIC50:  60nMpH: 7.5 T: 2°CAssay Description:The phospholipase A2 activity of LCAT was assayed using lecithin and apoA-I containing [9,10-3H] dipalmitoylphosphatidylcholine (DPPC) and measuremen...More data for this Ligand-Target Pair
In DepthDetails
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109394(CHEMBL3601219)
Affinity DataIC50:  66nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against Leukotriene A4 hydrolase from human leukocytesMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50088591(CHEMBL3577511)
Affinity DataIC50:  80nMAssay Description:Inhibition of AChE in human erythrocytes using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50:  86nMAssay Description:Inhibition of human recombinant ARG1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  110nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50597797(CHEMBL4459180)
Affinity DataIC50:  110nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109395(CHEMBL3601220)
Affinity DataIC50:  118nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50013397(CHEMBL3263380)
Affinity DataIC50:  120nMAssay Description:Inhibition of autophosphorylation of recombinant his-tagged EGFR (amino acid 645-1186) (unknown origin) expressed in Sf-9 cells after 10 mins by time...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  120nMAssay Description:Inhibition of electric eel AchE using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50088591(CHEMBL3577511)
Affinity DataIC50:  120nMAssay Description:Inhibition of AChE in rat cortex using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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