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Target
Calpain-2 catalytic subunit
Ligand
BDBM50284777
Substrate
n/a
Meas. Tech.
ChEBML_43857
IC50
80±n/a nM
Citation
 Woo, J; Sigeizumi, S; Yamaguchi, K; Sugimoto, K; Kobori, T; Tsuji, T; Kondo, K Peptidyl aldehyde derivatives as potent and selective inhibitors of cathepsin L Bioorg Med Chem Lett 5:1501-1504 (1995)    Article 
Target
Name:
Calpain-2 catalytic subunit
Synonyms:
CAN2_HUMAN | CANP 2 | CANPL2 | CAPN2 | Calcium-activated neutral proteinase 2 | Calpain 2 | Calpain M-type | Calpain large polypeptide L2 | Calpain-2 (m-Calpain) | Calpain-2 catalytic subunit | Calpain-2 large subunit | Calpain1/2 | M-calpain | Millimolar-calpain | calpain
Type:
Protein
Mol. Mass.:
79965.18
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
700
Sequence:
MAGIAAKLAKDREAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL
  
Inhibitor
Name:
BDBM50284777
Synonyms:
CHEMBL36969 | Z-Phe-Tyr(Bu)-H
Type:
Small organic molecule
Emp. Form.:
C30H34N2O6
Mol. Mass.:
518.6008
SMILES:
CCCCOc1ccc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)C(O)=O)cc1
Structure:
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