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Target
Calpain-2 catalytic subunit
Ligand
BDBM50284779
Substrate
n/a
Meas. Tech.
ChEBML_43857
IC50
184±n/a nM
Citation
 Woo, J; Sigeizumi, S; Yamaguchi, K; Sugimoto, K; Kobori, T; Tsuji, T; Kondo, K Peptidyl aldehyde derivatives as potent and selective inhibitors of cathepsin L Bioorg Med Chem Lett 5:1501-1504 (1995)    Article 
Target
Name:
Calpain-2 catalytic subunit
Synonyms:
CAN2_HUMAN | CANP 2 | CANPL2 | CAPN2 | Calcium-activated neutral proteinase 2 | Calpain 2 | Calpain M-type | Calpain large polypeptide L2 | Calpain-2 (m-Calpain) | Calpain-2 catalytic subunit | Calpain-2 large subunit | Calpain1/2 | M-calpain | Millimolar-calpain | calpain
Type:
Protein
Mol. Mass.:
79965.18
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
700
Sequence:
MAGIAAKLAKDREAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL
  
Inhibitor
Name:
BDBM50284779
Synonyms:
CHEMBL36146 | Z-Phe-Tyr-H
Type:
Small organic molecule
Emp. Form.:
C26H26N2O6
Mol. Mass.:
462.4944
SMILES:
OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
Structure:
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