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Target
Cholesteryl ester transfer protein
Ligand
BDBM50286607
Substrate
n/a
Meas. Tech.
ChEMBL_48927 (CHEMBL660757)
IC50
196000±n/a nM
Citation
 Coval, SJ; Conover, MA; Mierzwa, R; King, A; Puar, MS; Phife, DW; Pai, J; Burrier, RE; Ahn, H; Boykow, GC; Patel, M; Pomponi, SA Wiedendiol-A and -B, cholesteryl ester transfer protein inhibitors from the marine sponge Xestospongia wiedenmayeri Bioorg Med Chem Lett 5:605-610 (1995)    Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50286607
Synonyms:
(3bR,5aR,6S,7S,9aR,9bR)-7-Hydroxy-6-hydroxymethyl-3b,6,9a-trimethyl-3b,5,5a,6,7,9,9a,9b,10,11-decahydro-4H-phenanthro[1,2-c]furan-8-one | CHEMBL156156 | SPONGIADIOL
Type:
Small organic molecule
Emp. Form.:
C20H28O4
Mol. Mass.:
332.4339
SMILES:
C[C@]1(CO)[C@H](O)C(=O)C[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CCc2cocc12 |r|
Structure:
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