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Target
Plasmepsin II
Ligand
BDBM50071562
Substrate
n/a
Meas. Tech.
ChEBML_154921
Ki
560±n/a nM
Citation
 Carroll, CD; Patel, H; Johnson, TO; Guo, T; Orlowski, M; He, ZM; Cavallaro, CL; Guo, J; Oksman, A; Gluzman, IY; Connelly, J; Chelsky, D; Goldberg, DE; Dolle, RE Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett 8:2315-20 (1999) [PubMed]  Article 
Target
Name:
Plasmepsin II
Synonyms:
Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:
Enzyme
Mol. Mass.:
51482.09
Organism:
Plasmodium falciparum
Description:
P46925
Residue:
453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYENVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKTNYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
  
Inhibitor
Name:
BDBM50071562
Synonyms:
3-Hydroxy-4-{(S)-2-[2-(naphthalen-2-yloxy)-acetylamino]-2-phenyl-acetylamino}-5-phenyl-pentanoic acid butylamide | CHEMBL308036
Type:
Small organic molecule
Emp. Form.:
C35H39N3O5
Mol. Mass.:
581.7013
SMILES:
CCCCNC(=O)CC(O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)COc1ccc2ccccc2c1)c1ccccc1
Structure:
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