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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM3532
Substrate
n/a
Meas. Tech.
ChEBML_157940
IC50
>10000±n/a nM
Citation
 Wright, SW; Hageman, DL; McClure, LD; Carlo, AA; Treadway, JL; Mathiowetz, AM; Withka, JM; Bauer, PH Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines. Bioorg Med Chem Lett 11:17-21 (2001) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_PIG | FBP | FBP1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36781.07
Organism:
Sus scrofa (Pig)
Description:
Liver FBPase (P00636)
Residue:
338
Sequence:
MTDQAAFDTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK
  
Inhibitor
Name:
BDBM3532
Synonyms:
CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine | PD153035 Analog 31
Type:
Small organic molecule
Emp. Form.:
C16H14ClN3O2
Mol. Mass.:
315.754
SMILES:
COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
Structure:
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