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Found 111 with Last Name = 'bauer' and Initial = 'ph'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118009((6,7-Diethoxy-quinazolin-4-yl)-(3-thiazol-2-yl-phe...)
Affinity DataIC50:  2nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117952((6,7-Diethoxy-quinazolin-4-yl)-(3-furan-2-yl-pheny...)
Affinity DataIC50:  3nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095256((6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-4-fluor...)
Affinity DataIC50:  4nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117983((6,7-Diethoxy-quinazolin-4-yl)-(3-thiazol-5-yl-phe...)
Affinity DataIC50:  11nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117986((6,7-Diethoxy-quinazolin-4-yl)-[3-(1H-pyrazol-3-yl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117970((6,7-Diethoxy-quinazolin-4-yl)-(3-thiazol-4-yl-phe...)
Affinity DataIC50:  18nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81848(Bipiperidinyl carboxylic acid amide, 20)
Affinity DataIC50:  200nMAssay Description:Cell-based assay for CCR4 was developed to screen small-molecule compound library using a Fluorometric Imaging Plate Reader (FlIPR) assay to identify...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095256((6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-4-fluor...)
Affinity DataIC50:  250nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM4626(Anilinoquinazoline deriv. 9 | CHEMBL301018 | N-(3-...)
Affinity DataIC50:  290nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Sus scrofa (Pig))
Pfizer

Curated by ChEMBL
LigandPNGBDBM4626(Anilinoquinazoline deriv. 9 | CHEMBL301018 | N-(3-...)
Affinity DataIC50:  340nMAssay Description:Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117957(CHEMBL123678 | {4-[3-(6,7-Diethoxy-quinazolin-4-yl...)
Affinity DataIC50:  340nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat double mutant (Gln50Lys Gln55His) enzyme using malachite...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117961((6,7-Diethoxy-quinazolin-4-yl)-[3-(1H-[1,2,4]triaz...)
Affinity DataIC50:  390nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117955(4-[3-(6,7-Diethoxy-quinazolin-4-ylamino)-phenyl]-t...)
Affinity DataIC50:  520nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat double mutant (Gln50Lys Gln55His) enzyme using malachite...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095266((3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-quinazoli...)
Affinity DataIC50:  530nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118010(CHEMBL340660 | [3-(2-Amino-thiazol-4-yl)-phenyl]-(...)
Affinity DataIC50:  560nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117985((6,7-Diethoxy-quinazolin-4-yl)-(3-oxazol-4-yl-phen...)
Affinity DataIC50:  720nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Sus scrofa (Pig))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095256((6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-4-fluor...)
Affinity DataIC50:  770nMAssay Description:Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117947((6,7-Diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazo...)
Affinity DataIC50:  790nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat double mutant (Gln50Lys Gln55His) enzyme using malachite...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  800nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095259((6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)...)
Affinity DataIC50:  900nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Sus scrofa (Pig))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004952(3-(2-Carboxy-ethyl)-4,6-dichloro-1H-indole-2-carbo...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity of the compound against Fructose-1,6-bisphosphatase (F16BPase) in porcine kidneyMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117992((6,7-Diethoxy-quinazolin-4-yl)-(3-pyrimidin-5-yl-p...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50:  1.30E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Sus scrofa (Pig))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095259((6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)...)
Affinity DataIC50:  1.60E+3nMAssay Description:Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095261((3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-a...)
Affinity DataIC50:  1.60E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM3556(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Affinity DataIC50:  1.70E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095273((6,7-Diethoxy-quinazolin-4-yl)-(3-iodo-phenyl)-ami...)
Affinity DataIC50:  2.10E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81834(Bipiperidinyl carboxylic acid amide, 7)
Affinity DataIC50:  2.30E+3nMAssay Description:Cell-based assay for CCR4 was developed to screen small-molecule compound library using a Fluorometric Imaging Plate Reader (FlIPR) assay to identify...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095264((6,7-Diethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)-...)
Affinity DataIC50:  2.40E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81830(Bipiperidinyl carboxylic acid amide, 3)
Affinity DataIC50:  2.50E+3nMAssay Description:Cell-based assay for CCR4 was developed to screen small-molecule compound library using a Fluorometric Imaging Plate Reader (FlIPR) assay to identify...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117957(CHEMBL123678 | {4-[3-(6,7-Diethoxy-quinazolin-4-yl...)
Affinity DataIC50:  2.90E+3nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat single mutant (Gln55His) enzyme using malachite green as...More data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095270((3-Bromo-phenyl)-[6-(2-methoxy-ethoxy)-quinazolin-...)
Affinity DataIC50:  2.90E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81837(Bipiperidinyl carboxylic acid amide, 1)
Affinity DataIC50:  3.00E+3nMAssay Description:Cell-based assay for CCR4 was developed to screen small-molecule compound library using a Fluorometric Imaging Plate Reader (FlIPR) assay to identify...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117955(4-[3-(6,7-Diethoxy-quinazolin-4-ylamino)-phenyl]-t...)
Affinity DataIC50:  3.00E+3nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat single mutant (Gln55His) enzyme using malachite green as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Sus scrofa (Pig))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095266((3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-quinazoli...)
Affinity DataIC50:  3.10E+3nMAssay Description:Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81836(Bipiperidinyl carboxylic acid amide, 9)
Affinity DataIC50:  3.50E+3nMAssay Description:Cell-based assay for CCR4 was developed to screen small-molecule compound library using a Fluorometric Imaging Plate Reader (FlIPR) assay to identify...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095268((3-Bromo-phenyl)-(7-ethoxy-6-nitro-quinazolin-4-yl...)
Affinity DataIC50:  3.60E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81832(Bipiperidinyl carboxylic acid amide, 6)
Affinity DataIC50:  3.70E+3nMAssay Description:Cell-based assay for CCR4 was developed to screen small-molecule compound library using a Fluorometric Imaging Plate Reader (FlIPR) assay to identify...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117947((6,7-Diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazo...)
Affinity DataIC50:  3.80E+3nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat single mutant(Gln55His) enzyme using malachite green ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Sus scrofa (Pig))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095261((3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-a...)
Affinity DataIC50:  3.90E+3nMAssay Description:Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM3570(8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]quinazol...)
Affinity DataIC50:  4.00E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM3561(4-[(3-Bromophenyl)amino]-6,7-dimethoxy-2-methylqui...)
Affinity DataIC50:  4.50E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117947((6,7-Diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazo...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81841(Bipiperidinyl carboxylic acid amide, 13)
Affinity DataIC50:  5.10E+3nMAssay Description:Cell-based assay for CCR4 was developed to screen small-molecule compound library using a Fluorometric Imaging Plate Reader (FlIPR) assay to identify...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81852(Bipiperidinyl carboxylic acid amide, 24)
Affinity DataIC50:  5.20E+3nMAssay Description:Cell-based assay for CCR4 was developed to screen small-molecule compound library using a Fluorometric Imaging Plate Reader (FlIPR) assay to identify...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81842(Bipiperidinyl carboxylic acid amide, 14)
Affinity DataIC50:  5.20E+3nMAssay Description:Cell-based assay for CCR4 was developed to screen small-molecule compound library using a Fluorometric Imaging Plate Reader (FlIPR) assay to identify...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81840(Bipiperidinyl carboxylic acid amide, 12)
Affinity DataIC50:  5.30E+3nMAssay Description:Cell-based assay for CCR4 was developed to screen small-molecule compound library using a Fluorometric Imaging Plate Reader (FlIPR) assay to identify...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095262((3-Bromo-phenyl)-[7-methoxy-6-(2-methoxy-ethoxy)-q...)
Affinity DataIC50:  5.50E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81829(Bipiperidinyl carboxylic acid amide, 2)
Affinity DataIC50:  5.90E+3nMAssay Description:Cell-based assay for CCR4 was developed to screen small-molecule compound library using a Fluorometric Imaging Plate Reader (FlIPR) assay to identify...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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