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Target
Transporter
Ligand
BDBM50114998
Substrate
n/a
Meas. Tech.
ChEBML_144989
Ki
22100±n/a nM
Citation
 Enyedy, IJ; Wang, J; Zaman, WA; Johnson, KM; Wang, S Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol. Bioorg Med Chem Lett 12:1775-8 (2002) [PubMed]  Article 
Target
Name:
Transporter
Synonyms:
Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters
Type:
PROTEIN
Mol. Mass.:
66787.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1463061
Residue:
597
Sequence:
MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI
  
Inhibitor
Name:
BDBM50114998
Synonyms:
4-(4-Chloro-phenyl)-3-(2-morpholin-4-yl-phenyl)-3H-thiazol-(2Z)-ylideneamine | CHEMBL50901
Type:
Small organic molecule
Emp. Form.:
C19H18ClN3OS
Mol. Mass.:
371.884
SMILES:
Clc1ccc(cc1)-c1csc(=N)n1-c1ccccc1N1CCOCC1 |(5.06,-7.73,;6.39,-8.49,;7.72,-7.71,;9.06,-8.49,;9.06,-10.04,;7.72,-10.81,;6.39,-10.04,;10.41,-10.81,;10.41,-12.35,;11.72,-13.11,;13.05,-12.35,;14.38,-13.12,;13.05,-10.81,;14.15,-9.71,;15.48,-10.48,;16.82,-9.71,;16.81,-8.17,;15.48,-7.4,;14.15,-8.17,;12.82,-7.4,;12.82,-5.86,;11.5,-5.09,;10.16,-5.86,;10.16,-7.4,;11.49,-8.17,)|
Structure:
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