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Target
Renin
Ligand
BDBM50017783
Substrate
n/a
Meas. Tech.
ChEBML_195953
pH
6±n/a
IC50
0.550±n/a nM
Comments
extracted
Citation
 Rosenberg, SH; Woods, KW; Kleinert, HD; Stein, H; Nellans, HN; Hoffman, DJ; Spanton, SG; Pyter, RA; Cohen, J; Egan, DA Azido glycols: potent, low molecular weight renin inhibitors containing an unusual post scissile site residue. J Med Chem 32:1371-8 (1989) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50017783
Synonyms:
CHEMBL440779 | N-{1-[1-(4-Azido-1-cyclohexylmethyl-2,3-dihydroxy-butylcarbamoyl)-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-isobutyramide
Type:
Small organic molecule
Emp. Form.:
C30H44N8O5
Mol. Mass.:
596.721
SMILES:
CC(C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](CC1CCCCC1)[C@H](O)[C@H](O)CN=[N+]=[N-]
Structure:
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