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Found 108 with Last Name = 'hoffman' and Initial = 'dj'
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230127(CHEMBL407606)
Affinity DataKi:  0.0245nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230129(CHEMBL407123)
Affinity DataKi:  0.0427nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230120(CHEMBL405737)
Affinity DataKi:  0.0776nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230123(CHEMBL385042)
Affinity DataKi:  0.0933nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230122(CHEMBL415571)
Affinity DataKi:  0.155nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230126(CHEMBL385468)
Affinity DataKi:  0.186nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230124(CHEMBL429240)
Affinity DataKi:  0.209nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230128(CHEMBL437798)
Affinity DataKi:  0.380nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230130(CHEMBL266205)
Affinity DataKi:  1.40nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230121(CHEMBL217405)
Affinity DataKi:  2.20nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230125(CHEMBL274682)
Affinity DataKi:  2.60nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230119(CHEMBL414071)
Affinity DataKi:  9.30nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080764((S)-2-({5-[(Benzyl-pyridin-3-yl-amino)-methyl]-2'-...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080765((S)-2-({5-[(Cyclohexylmethyl-pyridin-3-yl-amino)-m...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080742((S)-2-[(5-{[Benzyl-(5-fluoro-pyridin-3-yl)-amino]-...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080748((S)-2-[(5-{[(3,5-Difluoro-benzyl)-thiazol-5-ylmeth...)
Affinity DataIC50:  0.200nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080743((S)-2-({5-[(Benzyl-thiazol-5-ylmethyl-amino)-methy...)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080747((S)-2-[(5-{[(3,5-Difluoro-benzyl)-phenyl-amino]-me...)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50067581((S)-2-{[2'-Methyl-5-(pyridin-3-ylaminomethyl)-biph...)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080750((S)-2-({5-[(Benzyl-pyrimidin-5-yl-amino)-methyl]-2...)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50067563((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphen...)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017780(CHEMBL284451 | {1-[1-(4-Azido-1-cyclohexylmethyl-2...)
Affinity DataIC50:  0.400nMpH: 6.0Assay Description:Inhibitory activity against purified human plasma renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017780(CHEMBL284451 | {1-[1-(4-Azido-1-cyclohexylmethyl-2...)
Affinity DataIC50:  0.400nMpH: 6.0Assay Description:Inhibitory activity against purified human renal renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080759((S)-2-{[2'-Methyl-4-phenethyl-5-(pyridin-3-yloxyme...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017783(CHEMBL440779 | N-{1-[1-(4-Azido-1-cyclohexylmethyl...)
Affinity DataIC50:  0.550nMpH: 6.0Assay Description:Inhibitory activity against purified human plasma renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017783(CHEMBL440779 | N-{1-[1-(4-Azido-1-cyclohexylmethyl...)
Affinity DataIC50:  0.550nMpH: 6.0Assay Description:Inhibitory activity against purified human plasma renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017782(CHEMBL280744 | Tetrahydro-pyran-4-carboxylic acid ...)
Affinity DataIC50:  0.700nMpH: 6.0Assay Description:Inhibitory activity against purified human plasma renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080744((S)-2-({5-[(Benzyl-pyrazin-2-yl-amino)-methyl]-2'-...)
Affinity DataIC50:  0.800nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080762((S)-2-{[4-Benzyl-2'-methyl-5-(pyridin-3-yloxymethy...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080745((S)-2-({5-[(Benzyl-phenyl-amino)-methyl]-2'-methyl...)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080763((S)-2-[(5-{[(3,5-Difluoro-benzyl)-pyridin-3-yl-ami...)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050056(2-[(R)-1-[(S)-2-(3-Cyclohexyl-3-methyl-ureido)-4-m...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity was evaluated against human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017777(CHEMBL281436 | N-[1-[1-(4-Azido-1-cyclohexylmethyl...)
Affinity DataIC50:  2nMpH: 6.0Assay Description:Inhibitory activity against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080761((S)-2-{[2'-Methyl-4-pentyl-5-(pyridin-3-yloxymethy...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017778(CHEMBL282757 | Morpholine-4-carboxylic acid {1-[1-...)
Affinity DataIC50:  2.40nMpH: 7.4Assay Description:Inhibitory activity against purified human plasma renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017778(CHEMBL282757 | Morpholine-4-carboxylic acid {1-[1-...)
Affinity DataIC50:  2.40nMpH: 7.4Assay Description:Inhibitory activity against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080760((S)-2-{[4-Ethyl-2'-methyl-5-(pyridin-3-yloxymethyl...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017773(CHEMBL280503 | Morpholine-4-carboxylic acid [1-[1-...)
Affinity DataIC50:  4nMpH: 6.0Assay Description:Inhibitory activity against purified human plasma renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050063(2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4...)
Affinity DataIC50:  4.60nMAssay Description:Inhibitory activity was evaluated against human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017774(CHEMBL29004 | {1-[1-(4-Azido-1-cyclohexylmethyl-2,...)
Affinity DataIC50:  4.80nMpH: 6.0Assay Description:Inhibitory activity against purified human renal renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017779(CHEMBL28679 | {1-[1-(4-Azido-1-cyclohexylmethyl-2-...)
Affinity DataIC50:  5.40nMpH: 6.0Assay Description:Inhibitory activity against purified human renal renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080751((S)-2-({5-[(Benzenesulfonyl-pyridin-3-yl-amino)-me...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080752((S)-2-({5-[(Benzyl-thiazol-2-ylmethyl-amino)-methy...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017775(CHEMBL29315 | {1-[1-(3-Azido-1-cyclohexylmethyl-2-...)
Affinity DataIC50:  7.5nMpH: 6.0Assay Description:Inhibitory activity against purified human renal renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017782(CHEMBL280744 | Tetrahydro-pyran-4-carboxylic acid ...)
Affinity DataIC50:  7.60nMpH: 7.4Assay Description:Inhibitory activity against purified human plasma renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017780(CHEMBL284451 | {1-[1-(4-Azido-1-cyclohexylmethyl-2...)
Affinity DataIC50:  9nMpH: 7.4Assay Description:Inhibitory activity against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050058(2-[(R)-1-((S)-2-Cyclohexylcarbamoyloxy-4-methyl-pe...)
Affinity DataIC50:  9.30nMAssay Description:Inhibitory activity was evaluated against human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017777(CHEMBL281436 | N-[1-[1-(4-Azido-1-cyclohexylmethyl...)
Affinity DataIC50:  10nMpH: 7.4Assay Description:Inhibitory activity against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017786(CHEMBL408084 | {1-[1-(4-Azido-1-cyclohexylmethyl-2...)
Affinity DataIC50:  10nMpH: 6.0Assay Description:Inhibitory activity against purified human renal renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050047(2-[(R)-1-[(S)-2-(3-Cyclohexyl-ureido)-4-methyl-pen...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity was evaluated against human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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