Reaction Details Report a problem with these data
Target
Vasopressin V2 receptor
Ligand
BDBM50368134
Substrate
n/a
Meas. Tech.
ChEBML_215037
Ki
140±n/a nM
Citation
 Bock, MG; DiPardo, RM; Williams, PD; Pettibone, DJ; Clineschmidt, BV; Ball, RG; Veber, DF; Freidinger, RM Receptor ligands which bind the oxytocin receptor with selectivity and high affinity. Chemical modification of a Streptomyces silvensis derived cyclic hexapeptide. J Med Chem 33:2321-3 (1990) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
AVPR V2 | Antidiuretic hormone receptor | Avpr2 | Renal-type arginine vasopressin receptor | V2R_RAT | VASOPRESSIN V2 | Vasopressin receptor
Type:
G-protein coupled receptor
Mol. Mass.:
40761.85
Organism:
Rat
Description:
n/a
Residue:
371
Sequence:
MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
  
Inhibitor
Name:
BDBM50368134
Synonyms:
CHEMBL1790544
Type:
Small organic molecule
Emp. Form.:
C40H50N8O5S
Mol. Mass.:
754.941
SMILES:
CC[C@@H](C)[C@@H]1NC(=S)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCC=NN2C(=O)[C@H]2CCC=NN2C1=O |c:44,53|
Structure:
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