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Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50001300
Substrate
n/a
Meas. Tech.
ChEMBL_52046 (CHEMBL666432)
IC50
250±n/a nM
Citation
 Zamboni, R; Belley, M; Champion, E; Charette, L; DeHaven, R; Frenette, R; Gauthier, JY; Jones, TR; Leger, S; Masson, P Development of a novel series of styrylquinoline compounds as high-affinity leukotriene D4 receptor antagonists: synthetic and structure-activity studies leading to the discovery of (+-)-3-[[[3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl][[3- (dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic J Med Chem 35:3832-44 (1992) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_CAVPO | CYSLTR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
  
Inhibitor
Name:
BDBM50001300
Synonyms:
3-((2-Carboxy-ethylsulfanyl)-{3-[3-(7-chloro-quinolin-2-yl)-propyl]-phenyl}-methylsulfanyl)-propionic sodium salt | CHEMBL339713
Type:
Small organic molecule
Emp. Form.:
C25H24ClNO4S2
Mol. Mass.:
502.046
SMILES:
[O-]C(=O)CCSC(SCCC([O-])=O)c1cccc(CCCc2ccc3ccc(Cl)cc3n2)c1
Structure:
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