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Target
Purine nucleoside phosphorylase
Ligand
BDBM50042802
Substrate
n/a
Meas. Tech.
ChEMBL_162040 (CHEMBL766680)
IC50
90000±n/a nM
Citation
 Erion, MD; Niwas, S; Rose, JD; Ananthan, S; Allen, M; Secrist, JA; Babu, YS; Bugg, CE; Guida, WC; Ealick, SE Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group. J Med Chem 36:3771-83 (1994) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Np | PNPH_MOUSE | Pnp | Pnp1
Type:
PROTEIN
Mol. Mass.:
32274.71
Organism:
Mus musculus
Description:
ChEMBL_162040
Residue:
289
Sequence:
MENEFTYEDYETTAKWLLQHTEYRPQVAVICGSGLGGLTAHLKEAQIFDYNEIPNFPQSTVQGHAGRLVFGLLNGRCCVMMQGRFHMYEGYSLSKVTFPVRVFHLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFCGQNPLRGPNDERFGVRFPAMSDAYDRDMRQKAFTAWKQMGEQRKLQEGTYVMLAGPNFETVAESRLLKMLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVVMDYENLEKANHMEVLDAGKAAAQTLERFVSILMESIPLPDRGS
  
Inhibitor
Name:
BDBM50042802
Synonyms:
2-Amino-7-(1-cyclohexyl-3-hydroxy-propyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL338124
Type:
Small organic molecule
Emp. Form.:
C15H22N4O2
Mol. Mass.:
290.3608
SMILES:
Nc1nc2c(c[nH]c2c(=O)[nH]1)C(CCO)C1CCCCC1
Structure:
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