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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50035105
Substrate
n/a
Meas. Tech.
ChEMBL_202043 (CHEMBL809516)
IC50
17±n/a nM
Citation
 Perregaard, J; Moltzen, EK; Meier, E; Sánchez, C Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. J Med Chem 38:1998-2008 (1995) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50035105
Synonyms:
1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro[1,3-dihydroisobenzofuran-1,4'-(hexahydropyridine)] | 1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro[1,3-dihydroisobenzofuran-1,4'-(hexahydropyridine)](Lu 28-179) | CHEMBL61479 | Lu 28-179 | Siramesine
Type:
Small organic molecule
Emp. Form.:
C30H31FN2O
Mol. Mass.:
454.5783
SMILES:
Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)OCc2ccccc32)c2ccccc12
Structure:
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