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Target
Translocator protein
Ligand
BDBM50021058
Substrate
n/a
Meas. Tech.
ChEMBL_37050 (CHEMBL652439)
Kd
>10±n/a nM
Citation
 Dalpiaz, A; Bertolasi, V; Borea, PA; Nacci, V; Fiorini, I; Campiani, G; Mennini, T; Manzoni, C; Novellino, E; Greco, G A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors. J Med Chem 38:4730-8 (1995) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50021058
Synonyms:
7-Chloro-1-methyl-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine | CHEMBL28333 | MEDAZEPAM
Type:
Small organic molecule
Emp. Form.:
C16H15ClN2
Mol. Mass.:
270.757
SMILES:
CN1CCN=C(c2ccccc2)c2cc(Cl)ccc12 |t:4|
Structure:
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