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Target
Translocator protein
Ligand
BDBM50029754
Substrate
n/a
Meas. Tech.
ChEMBL_37201 (CHEMBL650802)
Ki
95±n/a nM
Citation
 Dalpiaz, A; Bertolasi, V; Borea, PA; Nacci, V; Fiorini, I; Campiani, G; Mennini, T; Manzoni, C; Novellino, E; Greco, G A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors. J Med Chem 38:4730-8 (1995) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50029754
Synonyms:
CHEMBL286909 | Methanesulfonic acid 5-(4-methoxy-phenyl)-6-thia-10b-aza-benzo[e]azulen-4-yl ester
Type:
Small organic molecule
Emp. Form.:
C20H17NO4S2
Mol. Mass.:
399.483
SMILES:
COc1ccc(cc1)C1=C(OS(C)(=O)=O)c2cccn2-c2ccccc2S1 |c:9|
Structure:
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