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Target
Sterol O-acyltransferase 1
Ligand
BDBM50050300
Substrate
n/a
Meas. Tech.
ChEMBL_28797 (CHEMBL641707)
IC50
42000±n/a nM
Citation
 Picard, JA; O'Brien, PM; Sliskovic, DR; Anderson, MK; Bousley, RF; Hamelehle, KL; Krause, BR; Stanfield, RL Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 17. Structure-activity relationships of several series of compounds derived from N-chlorosulfonyl isocyanate. J Med Chem 39:1243-52 (1996) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50050300
Synonyms:
CHEMBL22297 | [2,6-Bis(1-methylethyl)-4-chloro]phenyl[[2,6-Bis(1-methylethyl)phenoxy]sulfonyl]carbamate
Type:
Small organic molecule
Emp. Form.:
C25H34ClNO5S
Mol. Mass.:
496.059
SMILES:
CC(C)c1cccc(C(C)C)c1OS(=O)(=O)NC(=O)Oc1c(cc(Cl)cc1C(C)C)C(C)C
Structure:
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