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Target
Polyunsaturated fatty acid 5-lipoxygenase
Ligand
BDBM50058561
Substrate
n/a
Meas. Tech.
ChEMBL_4202 (CHEMBL620004)
IC50
2100±n/a nM
Citation
 Stewart, AO; Bhatia, PA; Martin, JG; Summers, JB; Rodriques, KE; Martin, MB; Holms, JH; Moore, JL; Craig, RA; Kolasa, T; Ratajczyk, JD; Mazdiyasni, H; Kerdesky, FA; DeNinno, SL; Maki, RG; Bouska, JB; Young, PR; Lanni, C; Bell, RL; Carter, GW; Brooks, CD Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors. J Med Chem 40:1955-68 (1997) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid 5-lipoxygenase
Synonyms:
Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT
Type:
PROTEIN
Mol. Mass.:
78082.31
Organism:
Rattus norvegicus
Description:
ChEMBL_1432947
Residue:
673
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDEELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFHIHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGLFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEAIQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI
  
Inhibitor
Name:
BDBM50058561
Synonyms:
CHEMBL58785 | N-[(2E)-3-(2-furyl)-1-methylprop-2-enyl]-N-hydroxyurea
Type:
Small organic molecule
Emp. Form.:
C9H12N2O3
Mol. Mass.:
196.2032
SMILES:
CC(\C=C\c1ccco1)N(O)C(N)=O
Structure:
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