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Target
Translocator protein
Ligand
BDBM50060124
Substrate
n/a
Meas. Tech.
ChEMBL_39448 (CHEMBL653024)
IC50
287±n/a nM
Citation
 Trapani, G; Franco, M; Ricciardi, L; Latrofa, A; Genchi, G; Sanna, E; Tuveri, F; Cagetti, E; Biggio, G; Liso, G Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type. J Med Chem 40:3109-18 (1997) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50060124
Synonyms:
2-[6-Chloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-1-pyrrolidin-1-yl-ethanone | CHEMBL317473
Type:
Small organic molecule
Emp. Form.:
C19H17Cl2N3O
Mol. Mass.:
374.264
SMILES:
Clc1ccc(cc1)-c1nc2ccc(Cl)cn2c1CC(=O)N1CCCC1
Structure:
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