Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50060688
Substrate
n/a
Meas. Tech.
ChEMBL_2808 (CHEMBL617838)
IC50
413±n/a nM
Citation
 Campiani, G; Cappelli, A; Nacci, V; Anzini, M; Vomero, S; Hamon, M; Cagnotto, A; Fracasso, C; Uboldi, C; Caccia, S; Consolo, S; Mennini, T Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure. J Med Chem 40:3670-8 (1997) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT2C | 5-hydroxytryptamine receptor 2C | 5-hydroxytryptamine receptor 2C (5HT2c) | 5HT2C_RAT | 5ht1c | Htr1c | Htr2c | Serotonin (5-HT) receptor | Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
Type:
Enzyme
Mol. Mass.:
51935.10
Organism:
Rattus norvegicus (Rat)
Description:
P08909
Residue:
460
Sequence:
MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
  
Inhibitor
Name:
BDBM50060688
Synonyms:
7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxaline | 7-fluoro-4-(4-methylpiperazin-1-yl)pyrrolo[1,2-a]quinoxaline | CHEMBL341474
Type:
Small organic molecule
Emp. Form.:
C16H17FN4
Mol. Mass.:
284.3314
SMILES:
CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Structure:
Search PDB for entries with ligand similarity: