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Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50062013
Substrate
n/a
Meas. Tech.
ChEMBL_48268 (CHEMBL663173)
IC50
79±n/a nM
Citation
 Trivedi, BK; Padia, JK; Holmes, A; Rose, S; Wright, DS; Hinton, JP; Pritchard, MC; Eden, JM; Kneen, C; Webdale, L; Suman-Chauhan, N; Boden, P; Singh, L; Field, MJ; Hill, D Second generation"peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile. J Med Chem 41:38-45 (1998) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49196.59
Organism:
MOUSE
Description:
Cholecystokinin A CCKBR MOUSE::P56481
Residue:
453
Sequence:
MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCYVQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50062013
Synonyms:
CHEMBL436411 | [(R)-1-(Bicyclo[2.2.1]hept-2-ylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester
Type:
Small organic molecule
Emp. Form.:
C30H39N3O3
Mol. Mass.:
489.649
SMILES:
C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 |wU:1.13,wD:1.0,TLB:22:17:25:21.23.20,22:21:16.17.18:25,28:29:35:33.32,THB:20:19:16:21.22.23,20:21:16:19.18.25,15:16:25:21.23.20,(1.87,-7.07,;1.89,-8.44,;1.96,-10,;3.35,-10.7,;2.1,-11.62,;2.58,-13.11,;4.13,-13.1,;5.16,-14.25,;6.68,-13.93,;7.15,-12.45,;6.11,-11.31,;4.6,-11.62,;.49,-7.92,;-.8,-8.79,;-.78,-10.26,;-2.21,-8.09,;-3.5,-8.95,;-4.9,-8.37,;-5.95,-9.61,;-5.95,-11.21,;-7.46,-11.64,;-6.26,-10.35,;-6.26,-8.86,;-4.92,-10.85,;-3.5,-10.49,;-4.54,-11.79,;3.18,-7.76,;3.17,-6.37,;4.44,-8.49,;5.78,-7.73,;6.6,-6.67,;8.03,-6.27,;9.07,-7.24,;8.16,-8.37,;7.17,-7.54,;7.99,-4.93,)|
Structure:
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