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Target
Calpain-1 catalytic subunit
Ligand
BDBM50065402
Substrate
n/a
Meas. Tech.
ChEMBL_43870 (CHEMBL658530)
Ki
29±n/a nM
Citation
 Chatterjee, S; Gu, ZQ; Dunn, D; Tao, M; Josef, K; Tripathy, R; Bihovsky, R; Senadhi, SE; O'Kane, TM; McKenna, BA; Mallya, S; Ator, MA; Bozyczko-Coyne, D; Siman, R; Mallamo, JP D-amino acid containing, high-affinity inhibitors of recombinant human calpain I. J Med Chem 41:2663-6 (1998) [PubMed]  Article 
Target
Name:
Calpain-1 catalytic subunit
Synonyms:
CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1
Type:
Protein
Mol. Mass.:
81880.51
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
714
Sequence:
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
  
Inhibitor
Name:
BDBM50065402
Synonyms:
(R)-2-Methanesulfonylamino-4-methyl-pentanoic acid ((S)-1-benzyl-2-oxo-ethyl)-amide | CHEMBL91836
Type:
Small organic molecule
Emp. Form.:
C16H24N2O4S
Mol. Mass.:
340.438
SMILES:
CC(C)C[C@@H](NS(C)(=O)=O)C(=O)N[C@@H](Cc1ccccc1)C=O
Structure:
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