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Target
Calpain-1 catalytic subunit
Ligand
BDBM50065409
Substrate
n/a
Meas. Tech.
ChEMBL_43870 (CHEMBL658530)
Ki
130±n/a nM
Citation
Chatterjee, S; Gu, ZQ; Dunn, D; Tao, M; Josef, K; Tripathy, R; Bihovsky, R; Senadhi, SE; O'Kane, TM; McKenna, BA; Mallya, S; Ator, MA; Bozyczko-Coyne, D; Siman, R; Mallamo, JP D-amino acid containing, high-affinity inhibitors of recombinant human calpain I. J Med Chem 41:2663-6 (1998) [PubMed] Article
More Info.:
Target
Name:
Calpain-1 catalytic subunit
Synonyms:
CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1
Type:
Protein
Mol. Mass.:
81880.51
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
714
Sequence:
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
Inhibitor
Name:
BDBM50065409
Synonyms:
(S)-3-((R)-3-Benzyloxy-2-methanesulfonylamino-propionylamino)-N-ethyl-2-oxo-4-phenyl-butyramide | CHEMBL80553
Type:
Small organic molecule
Emp. Form.:
C23H29N3O6S
Mol. Mass.:
475.558
SMILES:
CCNC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](COCc1ccccc1)NS(C)(=O)=O