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Target
Histamine H3 receptor
Ligand
BDBM50092865
Substrate
n/a
Meas. Tech.
ChEMBL_86763 (CHEMBL698663)
Ki
7±n/a nM
Citation
 Stark, H; Sadek, B; Krause, M; Hüls, A; Ligneau, X; Ganellin, CR; Arrang, JM; Schwartz, JC; Schunack, W Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds. J Med Chem 43:3987-94 (2000) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50092865
Synonyms:
1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-heptan-1-one; compound with but-2-enedioic acid(0.25M H2O) | CHEMBL449398
Type:
Small organic molecule
Emp. Form.:
C19H26N2O2
Mol. Mass.:
314.4219
SMILES:
CCCCCCC(=O)c1ccc(OCCCc2cnc[nH]2)cc1
Structure:
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