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Target
Translocator protein
Ligand
BDBM50059755
Substrate
n/a
Meas. Tech.
ChEMBL_222291 (CHEMBL823051)
IC50
2.9±n/a nM
Citation
 Anzini, M; Cappelli, A; Vomero, S; Seeber, M; Menziani, MC; Langer, T; Hagen, B; Manzoni, C; Bourguignon, JJ Mapping and fitting the peripheral benzodiazepine receptor binding site by carboxamide derivatives. Comparison of different approaches to quantitative ligand-receptor interaction modeling. J Med Chem 44:1134-50 (2001) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50059755
Synonyms:
4-(2-Fluoro-phenyl)-3-methyl-quinoline-2-carboxylic acid sec-butyl-methyl-amide | CHEMBL15003
Type:
Small organic molecule
Emp. Form.:
C22H23FN2O
Mol. Mass.:
350.4292
SMILES:
CCC(C)N(C)C(=O)c1nc2ccccc2c(c1C)-c1ccccc1F |(5.27,-7.89,;3.94,-8.66,;3.95,-10.2,;5.3,-10.97,;2.62,-10.99,;2.64,-12.53,;1.29,-10.23,;1.27,-8.69,;-.04,-11.01,;-1.38,-10.25,;-2.7,-11.02,;-4.04,-10.25,;-5.37,-11.04,;-5.37,-12.58,;-4.04,-13.35,;-2.7,-12.56,;-1.37,-13.33,;-.02,-12.55,;1.31,-13.31,;-1.37,-14.87,;-2.7,-15.64,;-2.7,-17.18,;-1.37,-17.95,;-.02,-17.16,;-.04,-15.63,;1.29,-14.86,)|
Structure:
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