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Target
Translocator protein
Ligand
BDBM50098684
Substrate
n/a
Meas. Tech.
ChEMBL_222291 (CHEMBL823051)
IC50
2895±n/a nM
Citation
 Anzini, M; Cappelli, A; Vomero, S; Seeber, M; Menziani, MC; Langer, T; Hagen, B; Manzoni, C; Bourguignon, JJ Mapping and fitting the peripheral benzodiazepine receptor binding site by carboxamide derivatives. Comparison of different approaches to quantitative ligand-receptor interaction modeling. J Med Chem 44:1134-50 (2001) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50098684
Synonyms:
2-[(Benzyl-ethyl-amino)-methyl]-4-phenyl-quinoline-3-carboxylic acid benzylamide | CHEMBL15645
Type:
Small organic molecule
Emp. Form.:
C33H31N3O
Mol. Mass.:
485.6187
SMILES:
CCN(Cc1ccccc1)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1ccccc1
Structure:
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