Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50098685
Substrate
n/a
Meas. Tech.
ChEMBL_222291 (CHEMBL823051)
IC50
2479±n/a nM
Citation
Anzini, M; Cappelli, A; Vomero, S; Seeber, M; Menziani, MC; Langer, T; Hagen, B; Manzoni, C; Bourguignon, JJ Mapping and fitting the peripheral benzodiazepine receptor binding site by carboxamide derivatives. Comparison of different approaches to quantitative ligand-receptor interaction modeling. J Med Chem 44:1134-50 (2001) [PubMed] Article
More Info.:
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
Inhibitor
Name:
BDBM50098685
Synonyms:
2-[(Benzyl-ethyl-amino)-methyl]-4-phenyl-quinoline-3-carboxylic acid (4-chloro-phenyl)-methyl-amide | CHEMBL417442
Type:
Small organic molecule
Emp. Form.:
C33H30ClN3O
Mol. Mass.:
520.064
SMILES:
CCN(Cc1ccccc1)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1