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Target
Translocator protein
Ligand
BDBM50059733
Substrate
n/a
Meas. Tech.
ChEMBL_222291 (CHEMBL823051)
IC50
780±n/a nM
Citation
 Anzini, M; Cappelli, A; Vomero, S; Seeber, M; Menziani, MC; Langer, T; Hagen, B; Manzoni, C; Bourguignon, JJ Mapping and fitting the peripheral benzodiazepine receptor binding site by carboxamide derivatives. Comparison of different approaches to quantitative ligand-receptor interaction modeling. J Med Chem 44:1134-50 (2001) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50059733
Synonyms:
8-sec-Butyl-5-phenyl-8,9,10,11-tetrahydro-6,8-diaza-cyclohepta[a]naphthalen-7-one | CHEMBL15255
Type:
Small organic molecule
Emp. Form.:
C23H24N2O
Mol. Mass.:
344.4495
SMILES:
CCC(C)N1CCCc2c(nc(-c3ccccc3)c3ccccc23)C1=O
Structure:
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