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Target
Translocator protein
Ligand
BDBM50059752
Substrate
n/a
Meas. Tech.
ChEMBL_222291 (CHEMBL823051)
IC50
10±n/a nM
Citation
 Anzini, M; Cappelli, A; Vomero, S; Seeber, M; Menziani, MC; Langer, T; Hagen, B; Manzoni, C; Bourguignon, JJ Mapping and fitting the peripheral benzodiazepine receptor binding site by carboxamide derivatives. Comparison of different approaches to quantitative ligand-receptor interaction modeling. J Med Chem 44:1134-50 (2001) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50059752
Synonyms:
8,9-Dihydro-7-oxa-5-aza-benzo[6,7]cyclohepta[1,2-a]naphthalene-6-carboxylic acid benzyl-methyl-amide | CHEMBL416713
Type:
Small organic molecule
Emp. Form.:
C26H22N2O2
Mol. Mass.:
394.4651
SMILES:
CN(Cc1ccccc1)C(=O)c1nc2ccccc2c-2c1OCCc1ccccc-21
Structure:
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