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Target
Melanocortin receptor 3
Ligand
BDBM50121257
Substrate
n/a
Meas. Tech.
ChEMBL_106830 (CHEMBL717671)
IC50
2.5±n/a nM
Citation
 Grieco, P; Lavecchia, A; Cai, M; Trivedi, D; Weinberg, D; MacNeil, T; Van der Ploeg, LH; Hruby, VJ Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors. J Med Chem 45:5287-94 (2002) [PubMed]  Article 
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:
Enzyme
Mol. Mass.:
36044.86
Organism:
Homo sapiens (Human)
Description:
P41968
Residue:
323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
  
Inhibitor
Name:
BDBM50121257
Synonyms:
6-(2-Acetylamino-hexanoylamino)-20-[3-(diaminomethaniminium)-propyl]-17-(1H-indol-3-ylmethyl)-23-naphthalen-2-ylmethyl-5,8,16,19,22,25-hexaoxo-4,9,15,18,21,24-hexaaza-spiro[2.22]pentacosane-14-carboxylic acid amide | CID44366186 | PG-946
Type:
Small organic molecule
Emp. Form.:
C52H70N13O9
Mol. Mass.:
1021.1934
SMILES:
CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(N)=[NH2+])NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CC2)NC1=O)C(N)=O
Structure:
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