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Target
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
Ligand
BDBM50110686
Substrate
n/a
Meas. Tech.
ChEMBL_198010 (CHEMBL799062)
IC50
0.03±n/a nM
Citation
 McCluskey, A; Sim, AT; Sakoff, JA Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem 45:1151-75 (2002) [PubMed]  Article 
Target
Name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
Synonyms:
Serine-threonine protein phosphatase 2A regulatory subunit
Type:
PROTEIN
Mol. Mass.:
49694.81
Organism:
Gallus gallus
Description:
ChEMBL_161937
Residue:
426
Sequence:
DDDVAEADIISTVEFNHCGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHHAWHPKENIIAVATTNNLYIFQDKMN
  
Inhibitor
Name:
BDBM50110686
Synonyms:
14-Ethylidene-2-isopropyl-5-(6-methoxy-3,5-dimethyl-7-phenyl-hepta-1,3-dienyl)-6,13,18-trimethyl-3,7,12,15,19-pentaoxo-1,4,8,13tetraaza-cyclononadecane-9,17-dicarboxylic acid | CHEMBL415297
Type:
Small organic molecule
Emp. Form.:
C41H58N4O10
Mol. Mass.:
766.92
SMILES:
CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](C)[C@@H](CC(=O)C(=CC)N(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O)C(C)C |w:32.33|
Structure:
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