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Target
Transporter
Ligand
BDBM50127635
Substrate
n/a
Meas. Tech.
ChEMBL_144983 (CHEMBL754325)
Ki
20.5±n/a nM
Citation
 Zhou, J; Zhang, A; Kläss, T; Johnson, KM; Wang, CZ; Ye, YP; Kozikowski, AP Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites. J Med Chem 46:1997-2007 (2003) [PubMed]  Article 
Target
Name:
Transporter
Synonyms:
Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters
Type:
PROTEIN
Mol. Mass.:
66787.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1463061
Residue:
597
Sequence:
MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI
  
Inhibitor
Name:
BDBM50127635
Synonyms:
5-(4-Thiophen-3-yl-benzylidene)-3-aza-tricyclo[4.4.2.0*3,8*]dodecane-7-carboxylic acid methyl ester | CHEMBL61529
Type:
Small organic molecule
Emp. Form.:
C24H27NO2S
Mol. Mass.:
393.542
SMILES:
COC(=O)C1C2CCC3CN2C\C(=C/c2ccc(cc2)-c2ccsc2)C1CC3 |THB:2:4:12.11:9.26.8.27,6:5:12.11:9.26.8.27|
Structure:
Search PDB for entries with ligand similarity: