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Target
Translocator protein
Ligand
BDBM50131726
Substrate
n/a
Meas. Tech.
ChEMBL_37039 (CHEMBL650835)
IC50
12±n/a nM
Citation
 Cappelli, A; Pericot Mohr, G; Gallelli, A; Giuliani, G; Anzini, M; Vomero, S; Fresta, M; Porcu, P; Maciocco, E; Concas, A; Biggio, G; Donati, A Structure-activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands. J Med Chem 46:3568-71 (2003) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rat
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50131726
Synonyms:
3-Diethylaminomethyl-4-phenyl-quinoline-2-carboxylic acid benzyl-methyl-amide | CHEMBL331928
Type:
Small organic molecule
Emp. Form.:
C29H31N3O
Mol. Mass.:
437.5759
SMILES:
CCN(CC)Cc1c(nc2ccccc2c1-c1ccccc1)C(=O)N(C)Cc1ccccc1
Structure:
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