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Target
Serine protease 1
Ligand
BDBM50131985
Substrate
n/a
Meas. Tech.
ChEMBL_39228 (CHEMBL655074)
Ki
16±n/a nM
Citation
 Costanzo, MJ; Yabut, SC; Almond, HR; Andrade-Gordon, P; Corcoran, TW; De Garavilla, L; Kauffman, JA; Abraham, WM; Recacha, R; Chattopadhyay, D; Maryanoff, BE Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone. J Med Chem 46:3865-76 (2003) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50131985
Synonyms:
1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [4-amino-1-(benzothiazole-2-carbonyl)-butyl]-amide; TFA | CHEMBL339764
Type:
Small organic molecule
Emp. Form.:
C19H24N4O4S
Mol. Mass.:
404.483
SMILES:
CC(=O)N1C[C@H](O)C[C@H]1C(=O)NC(CCCN)C(=O)c1nc2ccccc2s1
Structure:
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