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Target
Somatostatin receptor type 2
Ligand
BDBM50136759
Substrate
n/a
Meas. Tech.
ChEMBL_200672 (CHEMBL806163)
IC50
533±n/a nM
Citation
 Rivier, J; Erchegyi, J; Hoeger, C; Miller, C; Low, W; Wenger, S; Waser, B; Schaer, JC; Reubi, JC Novel sst(4)-selective somatostatin (SRIF) agonists. 1. Lead identification using a betide scan. J Med Chem 46:5579-86 (2003) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS-2-R | SS2-R | SS2R | SSR2_HUMAN | SSTR2 | Somatostatin receptor type 2 (SSTR2)
Type:
Enzyme
Mol. Mass.:
41344.94
Organism:
Homo sapiens (Human)
Description:
P30874
Residue:
369
Sequence:
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Inhibitor
Name:
BDBM50136759
Synonyms:
(4S,7R,10S,13R,16S,22S,25R)-25-amino-13-(4-aminobutyl)-18-[benzoyl(methyl)carbamoyl]-7,22-dibenzyl-4-carboxy-10-[(1R)-1-hydroxyethyl]-16-(1H-indol-3-ylmethyl)-6,9,12,15,21,24-hexaoxo-1,2-dithia-5,8,11,14,17,18,20,23-octaazacyclohexacosan-19-olate | Peptide analogue
Type:
Small organic molecule
Emp. Form.:
C55H67N12O12S2
Mol. Mass.:
1152.324
SMILES:
C[C@@H](O)[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NN(C([O-])NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(O)=O)C(=O)N(C)C(=O)c1ccccc1
Structure:
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