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Target
Somatostatin receptor type 1
Ligand
BDBM50136766
Substrate
n/a
Meas. Tech.
ChEMBL_200535 (CHEMBL805039)
IC50
45±n/a nM
Citation
 Rivier, J; Erchegyi, J; Hoeger, C; Miller, C; Low, W; Wenger, S; Waser, B; Schaer, JC; Reubi, JC Novel sst(4)-selective somatostatin (SRIF) agonists. 1. Lead identification using a betide scan. J Med Chem 46:5579-86 (2003) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 1
Synonyms:
SOMATOSTATIN SST1 | SRIF-2 | SS-1-R | SS1-R | SS1R | SSR1_HUMAN | SSTR1 | Somatostatin receptor type 1 (SSTR1)
Type:
Enzyme
Mol. Mass.:
42692.81
Organism:
Homo sapiens (Human)
Description:
P30872
Residue:
391
Sequence:
MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL
  
Inhibitor
Name:
BDBM50136766
Synonyms:
(13R,25S)-26-Amino-7-(S)-1-benzyl-4-(S)-carboxy-17-((R)-1H-indol-3-ylmethyl)-10-(S)-methyl-13-methyl-6,9,12,16,19,22,25-heptaoxo-20-((S)-phenylmethyl)-23-((R)-phenylmethyl)-1,2-dithia-5,8,11,13,15,18,21,24-octaaza-cycloheptacosan-14-ol anion | CID44368405 | sst4-selective analogue 21
Type:
Small organic molecule
Emp. Form.:
C50H57N10O10S2
Mol. Mass.:
1022.179
SMILES:
C[C@@H]1NC(=O)N(C)[C@H]([O-])NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Structure:
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