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Target
Histamine N-methyltransferase
Ligand
BDBM50126884
Substrate
n/a
Meas. Tech.
ChEMBL_87236 (CHEMBL696456)
IC50
10400±n/a nM
Citation
 Mikó, T; Ligneau, X; Pertz, HH; Ganellin, CR; Arrang, JM; Schwartz, JC; Schunack, W; Stark, H Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds. J Med Chem 46:1523-30 (2003) [PubMed]  Article 
Target
Name:
Histamine N-methyltransferase
Synonyms:
HNMT_RAT | Hnmt
Type:
PROTEIN
Mol. Mass.:
33931.03
Organism:
Rattus norvegicus
Description:
ChEMBL_87236
Residue:
295
Sequence:
MASFMRSLFSDHSRYVESFRRFLNNSTEHQCMQEFMDKKLPGIIARIGETKAEIKILSIGGGAGEIDLQILSKVQAQYPGICINNEVVEPNAEQIVKYKELVAKTSNMENIKFAWHKETSSEYQKRVVEEDEEPPKWDFIHMIQMLYYVKDIPATLKFFHGLLAANAKILIILVSGTSGWEKLWKKYGFRLPRDDLCQYVTSSDLAQILDDLGIKYECYDLLSTMDITDCFIDGNENGDLLWDFLTETCNFIKTAPLDLKEEIMKDLQEPEFSVKKEGKVLFNNNLSFIVVEANV
  
Inhibitor
Name:
BDBM50126884
Synonyms:
1-[4-(4-Piperidin-1-ylmethyl-benzyloxy)-phenyl]-ethanone; compound with oxalic acid | CHEMBL39603
Type:
Small organic molecule
Emp. Form.:
C21H25NO2
Mol. Mass.:
323.4287
SMILES:
CC(=O)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1
Structure:
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