Reaction Details Report a problem with these data
Target
Sodium/bile acid cotransporter
Ligand
BDBM50150325
Substrate
n/a
Meas. Tech.
ChEMBL_311837 (CHEMBL834279)
IC50
1.3±n/a nM
Citation
Tu, N; Link, JT; Sorensen, BK; Emery, M; Grynfarb, M; Goos-Nilsson, A; Nguyen, B Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator. Bioorg Med Chem Lett 14:4179-83 (2004) [PubMed] Article
More Info.:
Target
Name:
Sodium/bile acid cotransporter
Synonyms:
Bile acid transporter | NTCP_RAT | Ntcp | Slc10a1
Type:
PROTEIN
Mol. Mass.:
39307.44
Organism:
Rattus norvegicus
Description:
ChEMBL_311837
Residue:
362
Sequence:
MEVHNVSAPFNFSLPPGFGHRATDKALSIILVLMLLLIMLSLGCTMEFSKIKAHLWKPKGVIVALVAQFGIMPLAAFLLGKIFHLSNIEALAILICGCSPGGNLSNLFTLAMKGDMNLSIVMTTCSSFSALGMMPLLLYVYSKGIYDGDLKDKVPYKGIMISLVIVLIPCTIGIVLKSKRPHYVPYILKGGMIITFLLSVAVTALSVINVGNSIMFVMTPHLLATSSLMPFSGFLMGYILSALFQLNPSCRRTISMETGFQNIQLCSTILNVTFPPEVIGPLFFFPLLYMIFQLAEGLLIIIIFRCYEKIKPPKDQTKITYKAAATEDATPAALEKGTHNGNIPPLQPGPSPNGLNSGQMAN
Inhibitor
Name:
BDBM50150325
Synonyms:
3-[4-(4-{[Benzyl-(3-methanesulfonylamino-2-methyl-phenyl)-amino]-methyl}-phenoxy)-phenyl]-propionic acid | CHEMBL182472
Type:
Small organic molecule
Emp. Form.:
C31H32N2O5S
Mol. Mass.:
544.661
SMILES:
Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2ccc(CCC(O)=O)cc2)cc1