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Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50167887
Substrate
n/a
Meas. Tech.
ChEMBL_303234 (CHEMBL827199)
Ki
>10000±n/a nM
Citation
 Hattori, K; Tanaka, A; Okitsu, O; Tabuchi, S; Taniguchi, K; Nishio, M; Koyama, S; Higaki, M; Seki, J; Sakane, K Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3. Bioorg Med Chem Lett 15:3091-5 (2005) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM50167887
Synonyms:
(R)-2-(6-((diphenylcarbamoyloxy)methyl)-6-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | CHEMBL196779 | {(R)-6-[(Diphenylcarbamoyloxy)-methyl]-6-hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yloxy}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C26H25NO6
Mol. Mass.:
447.4798
SMILES:
OC(=O)COc1cccc2C[C@@](O)(COC(=O)N(c3ccccc3)c3ccccc3)CCc12
Structure:
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