Reaction Details Report a problem with these data
Target
Coagulation factor VII
Ligand
BDBM50165513
Substrate
n/a
Meas. Tech.
ChEMBL_302325 (CHEMBL828912)
Ki
1011±n/a nM
Citation
 Buckman, BO; Chou, YL; McCarrick, M; Liang, A; Lentz, D; Mohan, R; Morrissey, MM; Shaw, KJ; Trinh, L; Light, DR Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors. Bioorg Med Chem Lett 15:2249-52 (2005) [PubMed]  Article 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM50165513
Synonyms:
(R)-2-[(7-Carbamimidoyl-naphthalen-2-ylmethyl)-(naphthalene-1-carbonyl)-amino]-4-methyl-pentanoic acid
Type:
Small organic molecule
Emp. Form.:
C29H29N3O3
Mol. Mass.:
467.5589
SMILES:
CC(C)CC(N(Cc1ccc2ccc(cc2c1)C(N)=N)C(=O)c1cccc2ccccc12)C(O)=O
Structure:
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