Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50165513
Substrate
n/a
Meas. Tech.
ChEMBL_302274 (CHEMBL830293)
Ki
1609±n/a nM
Citation
 Buckman, BO; Chou, YL; McCarrick, M; Liang, A; Lentz, D; Mohan, R; Morrissey, MM; Shaw, KJ; Trinh, L; Light, DR Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors. Bioorg Med Chem Lett 15:2249-52 (2005) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bos taurus (bovine)
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
  
Inhibitor
Name:
BDBM50165513
Synonyms:
(R)-2-[(7-Carbamimidoyl-naphthalen-2-ylmethyl)-(naphthalene-1-carbonyl)-amino]-4-methyl-pentanoic acid
Type:
Small organic molecule
Emp. Form.:
C29H29N3O3
Mol. Mass.:
467.5589
SMILES:
CC(C)CC(N(Cc1ccc2ccc(cc2c1)C(N)=N)C(=O)c1cccc2ccccc12)C(O)=O
Structure:
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