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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50164654
Substrate
n/a
Meas. Tech.
ChEMBL_302539 (CHEMBL875215)
Ki
37±n/a nM
Citation
 Boyle, NA; Rajwanshi, VK; Prhavc, M; Wang, G; Fagan, P; Chen, F; Ewing, GJ; Brooks, JL; Hurd, T; Leeds, JM; Bruice, TW; Cook, PD Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. J Med Chem 48:2695-700 (2005) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50164654
Synonyms:
CHEMBL370031 | [[[4-(2-amino-6-oxo-3,9-dihydropurin-9-yl)-1-cyclopent-2-enyl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
Type:
Small organic molecule
Emp. Form.:
C11H16N5O11P3
Mol. Mass.:
487.1929
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C=C1 |c:30|
Structure:
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