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Found 484 with Last Name = 'boyle' and Initial = 'na'
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataKi:  20nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164642(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  23nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164639(2'-3'-dideoxy-7-deaza-guaninetriphosphate | CHEMBL...)
Affinity DataKi:  25nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164652(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  34nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164654(CHEMBL370031 | [[[4-(2-amino-6-oxo-3,9-dihydropuri...)
Affinity DataKi:  37nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164637(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  45nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164638(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  46nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164647(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  47nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50145605(4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofura...)
Affinity DataKi:  51nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50370655(CHEMBL485652)
Affinity DataKi:  56nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164648(2'-deoxythymidine triphosphate | 5'-TTP | CHEMBL36...)
Affinity DataKi:  61nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164653(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  71nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164650(CHEMBL191725 | [[[3-fluoro-5-(5-methyl-2,4-dioxo-1...)
Affinity DataKi:  71nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50370476(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Affinity DataKi:  91nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164640(CHEMBL190609 | [[[[3-azido-5-(5-methyl-2,4-dioxo-1...)
Affinity DataKi:  94nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50138406(3TC Triphosphate | CHEMBL1230 | LAMIVUDINE | Lamiv...)
Affinity DataKi:  188nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Affinity DataKi:  200nMAssay Description:Binding affinity against Acetylcholinesterase of purified calf forebrain (CFB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Affinity DataKi:  200nMAssay Description:Binding affinity against Acetylcholinesterase of human RBCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164655(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  236nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164651(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  314nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Affinity DataKi:  400nMAssay Description:Binding affinity against Acetylcholinesterase of purified Octopus brain (OB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164656(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  438nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164645(CHEMBL192771 | [[[5-(4-amino-5-fluoro-2-oxo-1H-pyr...)
Affinity DataKi:  501nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164646(CHEMBL192371 | [[[5-(2,4-dioxo-1H-pyrimidin-1-yl)t...)
Affinity DataKi:  545nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM50059903(CHEMBL103873 | Trimethyl-(2-pentylsulfanylcarbonyl...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity against Acetylcholinesterase of purified calf forebrain (CFB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM39344(4-amino-N-[2-(diethylamino)ethyl]benzamide;hydroch...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity against Acetylcholinesterase of human RBCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM39344(4-amino-N-[2-(diethylamino)ethyl]benzamide;hydroch...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity against Acetylcholinesterase of purified calf forebrain (CFB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM39344(4-amino-N-[2-(diethylamino)ethyl]benzamide;hydroch...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity against Acetylcholinesterase of purified Octopus brain (OB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164643(({[({[5-(4-amino-5-fluoro-2-oxo-1,2-dihydropyrimid...)
Affinity DataKi:  1.77E+3nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM50059903(CHEMBL103873 | Trimethyl-(2-pentylsulfanylcarbonyl...)
Affinity DataKi:  2.00E+3nMAssay Description:In vitro inhibition of Acetylcholinesterase Activity in octopus brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM50059903(CHEMBL103873 | Trimethyl-(2-pentylsulfanylcarbonyl...)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity against Acetylcholinesterase of purified Octopus brain (OB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM50059899((2-Heptylsulfanylcarbonyloxy-ethyl)-trimethyl-ammo...)
Affinity DataKi:  1.00E+4nMAssay Description:Binding affinity against Acetylcholinesterase of purified calf forebrain (CFB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM50059899((2-Heptylsulfanylcarbonyloxy-ethyl)-trimethyl-ammo...)
Affinity DataKi:  2.00E+4nMAssay Description:Binding affinity against Acetylcholinesterase of human RBCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM50059899((2-Heptylsulfanylcarbonyloxy-ethyl)-trimethyl-ammo...)
Affinity DataKi:  4.00E+4nMAssay Description:Binding affinity against Acetylcholinesterase of purified Octopus brain (OB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Acetylcholinesterase activity of calf forebrainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM602728(2-[1-(2-Isoindolin-2-yl-6-methyl-4-oxo-chromen-8-y...)
Affinity DataIC50:  110nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6×his tagged p110<...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Acetylcholinesterase from human red blood cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Petra Pharma

US Patent
LigandPNGBDBM602728(2-[1-(2-Isoindolin-2-yl-6-methyl-4-oxo-chromen-8-y...)
Affinity DataIC50:  450nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6×his tagged p110<...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM602700(US11649227, Example 308 | US20230286960, Example 3...)
Affinity DataIC50: <500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM602701(US11649227, Example 309 | US20230286960, Example 3...)
Affinity DataIC50: <500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM602701(US11649227, Example 309 | US20230286960, Example 3...)
Affinity DataIC50: <500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM602702(US11649227, Example 310 | US20230286960, Example 3...)
Affinity DataIC50: <500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM602702(US11649227, Example 310 | US20230286960, Example 3...)
Affinity DataIC50: <500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM602703(US11649227, Example 319 | US20230286960, Example 3...)
Affinity DataIC50: <500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM602704(2-[1-(6-Fluoro-2-isoindolin-2-yl-3-methyl-4-oxo-ch...)
Affinity DataIC50: <500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM602704(2-[1-(6-Fluoro-2-isoindolin-2-yl-3-methyl-4-oxo-ch...)
Affinity DataIC50: <500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM602705(2-[1-[2-(4,4-Difluoro-1-piperidyl)-6-fluoro-3-meth...)
Affinity DataIC50: <500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM602705(2-[1-[2-(4,4-Difluoro-1-piperidyl)-6-fluoro-3-meth...)
Affinity DataIC50: <500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM602706(2-[1-[2-(6-Azaspiro[2.5]octan-6-yl)-6-fluoro-3-met...)
Affinity DataIC50: <500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM602706(2-[1-[2-(6-Azaspiro[2.5]octan-6-yl)-6-fluoro-3-met...)
Affinity DataIC50: <500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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