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Target
P-selectin glycoprotein ligand 1
Ligand
BDBM50201894
Substrate
n/a
Meas. Tech.
ChEMBL_423294 (CHEMBL855465)
IC50
1000000±n/a nM
Citation
 Kaila, N; Janz, K; DeBernardo, S; Bedard, PW; Camphausen, RT; Tam, S; Tsao, DH; Keith, JC; Nickerson-Nutter, C; Shilling, A; Young-Sciame, R; Wang, Q Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J Med Chem 50:21-39 (2007) [PubMed]  Article 
Target
Name:
P-selectin glycoprotein ligand 1
Synonyms:
P-selectin glycoprotein ligand 1 | P-selectin/P-selectin glycoprotein ligand 1 | SELPLG | SELPL_HUMAN
Type:
PROTEIN
Mol. Mass.:
43174.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_649756
Residue:
412
Sequence:
MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPPEMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPTEMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP
  
Inhibitor
Name:
BDBM50201894
Synonyms:
3-hydroxy-7,8-dimethyl-2-p-tolylquinoline-4-carboxylic acid | CHEMBL219230
Type:
Small organic molecule
Emp. Form.:
C19H17NO3
Mol. Mass.:
307.3432
SMILES:
Cc1ccc(cc1)-c1nc2c(C)c(C)ccc2c(C(O)=O)c1O
Structure:
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