Reaction Details Report a problem with these data
Target
Heme oxygenase 1
Ligand
BDBM50207198
Substrate
n/a
Meas. Tech.
ChEMBL_435911 (CHEMBL905312)
IC50
60±n/a nM
Citation
 Roman, G; Riley, JG; Vlahakis, JZ; Kinobe, RT; Brien, JF; Nakatsu, K; Szarek, WA Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring. Bioorg Med Chem 15:3225-34 (2007) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1
Type:
Enzyme
Mol. Mass.:
33005.15
Organism:
Rattus norvegicus (rat)
Description:
HO-1 obtained from rat spleen was used in enzyme assays.
Residue:
289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
  
Inhibitor
Name:
BDBM50207198
Synonyms:
1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanol hydrochloride | CHEMBL536746
Type:
Small organic molecule
Emp. Form.:
C13H15IN2O
Mol. Mass.:
342.1755
SMILES:
OC(CCc1ccc(I)cc1)Cn1ccnc1 |w:1.0|
Structure:
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